Characterizing proximal risk for depressive symptoms and suicidal ideation with acute cannabis use and withdrawal among adolescents using ecological momentary assessment: Study protocol.

ABSTRACT:

Background

Heavy cannabis use often co-occurs with symptoms of depression in adolescents. Adolescents with past-year cannabis use are at increased risk of major depressive episodes and cannabis use is more than twice as common in adolescents with depression compared to those without. This study seeks to disentangle relationships between acute cannabis use, withdrawal, and abstinence on proximal depression and suicide risk using ecological momentary assessment (EMA) within the context of a randomized controlled trial comparing the effects of cannabis abstinence to cannabis use as usual.

Methods

This study will enroll 200 adolescents aged 12-18 who have daily or near-daily cannabis use and current depressive symptoms. Participants will complete 12 study visits over a 10-week p

SUBMITTER: Feibus I 

PROVIDER: S-EPMC12714289 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature