GWAS and Replication Analysis of Apparent Treatment-Resistant Hypertension.

ABSTRACT:

Background

Resistant hypertension (RH), in which blood pressure remains elevated on ≥3 medications or controlled on ≥4 medications, increases the risk of adverse cardiovascular events nearly 50% more than primary hypertension. We sought to identify genetic drivers of RH in a reliable and generalizable manner.

Methods

We utilized FinnGen (discovery) and UKBB (UK Biobank, replication) data sets to identify potential genetic drivers of RH. Using standard RH definitions, we developed cohorts in each data set and performed genome-wide (genome-wide association studies) and transcriptome-wide association studies, as well as Mendelian randomization analysis to evaluate potential causal associations.

Results

We replicated 5 genetic loci in CASZ1, WNT2B, KCNK3, LSP1, and

SUBMITTER: Ebinger JE 

PROVIDER: S-EPMC12714304 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature