Cellularization in chytrid fungi uses distinct mechanisms from conventional cytokinesis and cellularization in animals and yeast.

ABSTRACT: Chytrid fungi provide a model for studying foam-like cellularization, where nuclei that are dispersed throughout the cytoplasm are synchronously compartmentalized into daughter cells. This organization poses geometric challenges not faced by cells undergoing conventional cytokinesis or Drosophila monolayer cellularization, where nuclei are organized in linear or planar arrangements with ready access to the plasma membrane. We use the chytrid Spizellomyces punctatus to show that chytrid cellularization begins with migration of nuclei and their attached centrosomes to the plasma membrane, where centrosome-associated vesicles mark sites of membrane invagination. These vesicles then extend inward, resulting in tubular furrows that branch and merge to create a honeycomb of polyhedral membrane c

SUBMITTER: Medina EM 

PROVIDER: S-EPMC12714308 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature