Bleeding, Drains, and Reoperation in Transmasculine Chest Surgery: What 2,534 Patients Tell Us About Tranexamic Acid.

ABSTRACT:

Background

Hematoma, seroma, and unplanned reoperation are the most frequent early complications after gender-affirming mastectomy with hematoma being the most common complication and the most common reason for reoperation. Tranexamic acid (TXA) is increasingly incorporated into enhanced-recovery protocols, yet its route-specific benefits remain unclear.

Methods

In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, databases were searched for comparative studies of TXA versus no TXA in transmasculine chest surgery. Review Manager 5.4 was used for statistical analysis.

Results

Seven retrospective cohorts (2534 patients) met the inclusion criteria. Overall, TXA significantly reduced hematoma risk by 41% (relative risk reductio

SUBMITTER: Pollack N 

PROVIDER: S-EPMC12714317 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature