Electrophysiological connections linking medial pulvinar, anterior nuclei of the thalamus and the hippocampus.

ABSTRACT: The Papez circuit traditionally highlights the anterior nuclei of the thalamus (ANT) as the main relay of hippocampal (HPC) output to the cortex, a view that has shaped neuromodulation strategies in temporal lobe epilepsy (TLE). However, recent studies suggest that the medial subregion of the pulvinar (mPLV)-a thalamic nucleus that has undergone significant evolutionary expansion throughout the mammalian brain evolution-also forms functional connections with medial temporal lobe (MTL) structures, including the HPC. To date, however, there is a lack of causal evidence directly comparing the connectivity between the HPC and the two thalamic nuclei (mPLV and ANT) and between the two thalamic structures within the same brains. In this study, we investigated 41 patients with medial (mTLE, n = 2

SUBMITTER: Togo M 

PROVIDER: S-EPMC12714353 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature