Biomimetic bone-vessel interface-on-a-chip for simulating periodontal physiological and pathological microenvironment.

ABSTRACT: Periodontitis is a chronic inflammatory disease affecting periodontal supporting tissues. Untreated, it causes irreversible alveolar bone destruction, ultimately leading to tooth loss. Periodontitis-associated pathogenic bacteria/metabolites and pro-inflammatory factors can initiate or exacerbate systemic disease through the circulation. Endothelial cells, forming the interface between circulation and tissues, play a key role in disease progression. As microfluidic organ chips enable the establishment of tissue-tissue interfaces and simulation of the in vivo microenvironment, we constructed a bone-vessel interface-on-a-chip. Within this physiological model, human bone marrow mesenchymal stem cells (hBMSCs) and human umbilical vein endothelial cells (HUVECs) were successfully co-cult

SUBMITTER: Chen C 

PROVIDER: S-EPMC12714388 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature