Treating a Childhood Cancer Survivor With Severe Aortic and Mitral Insufficiency Using TAVR and TMVR.

ABSTRACT:

Background

Adult survivors of childhood cancer experience an increased risk of cardiovascular disease. Surgical therapy is often high risk, particularly in survivors with history of mediastinal radiation. Transcatheter valve intervention for these patients is an evolving field.

Case summary

A 58-year-old woman with history of Hodgkin lymphoma s/p mediastinal radiation therapy and recent coronary artery bypass grafting presented with recurrent congestive heart failure. Echocardiography revealed moderate-severe aortic insufficiency, severe mitral regurgitation/mild mitral stenosis, and severe tricuspid regurgitation. After receiving transcatheter aortic valve replacement requiring extracorporeal membrane oxygenation support, she remained balloon pump dependent. Given her mild

SUBMITTER: Rajagopal JR 

PROVIDER: S-EPMC12714535 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature