TAF1 acetyltransferase promotes colorectal carcinoma metastasis by catalyzing β-hydroxybutyrylation of KCTD9.

ABSTRACT: Colorectal carcinoma (CRC) ranks as the second leading cause of cancer mortality worldwide. However, the mechanisms underlying CRC progression and metastasis, remain unclear. Our current research has identified that TATA-binding protein-associated factor-1 (TAF1), also as a lysine acetyltransferase, is frequently upregulated in CRC. Survival analysis has indicated that patients whose tumors expressed high TAF1 levels had poorer outcomes. Additionally, TAF1 overexpression fosters CRC proliferation, colorectal cancer stem-like cell stemness (CRCSC), and metastasis. Mechanistically, we first reported that lysine β-hydroxybutyrylation (Kbhb) modification of KCTD9 at K123 and K129, mediated by TAF1, facilitates the binding of TRIM21, thereby mediating the ubiquitination degradation of KCTD9. Th

SUBMITTER: Su J 

PROVIDER: S-EPMC12714577 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature