A risk-stratified model for predicting endometrial atypical hyperplasia and cancer to guide biopsy decisions in asymptomatic postmenopausal women.

ABSTRACT:

Background

Endometrial atypical hyperplasia (EAH) and endometrial cancer (EC) are increasingly detected in asymptomatic postmenopausal women. This often leads to delayed treatment. Risk stratification remains challenging, and single-factor models may not accurately identify high-risk individuals. This study aimed to develop and validate a multivariable prediction model for identifying EAH or EC in asymptomatic postmenopausal women.

Methods

This retrospective cohort study included asymptomatic postmenopausal women with endometrial pathology records from the Third Affiliated Hospital of Sun Yat-sen University, China (2021-2024). Candidate risk factors included demographics, clinical characteristics, and hematological parameters. The primary outcome was a composite of histologi

SUBMITTER: Wu S 

PROVIDER: S-EPMC12714613 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature