Associations of known and newly identified human milk oligosaccharides with infections in early childhood: the Ulm SPATZ health study.

ABSTRACT:

Introduction

Human milk oligosaccharides (HMOs) are bioactive components of breast milk that play a key role in shaping infant immune development and susceptibility to infections. This study investigated associations between 71 known and novel HMOs measured at 6 weeks and 6 months postpartum with infant infections during the first 2 years of life.

Methods

A total of 73 HMOs were analyzed in human milk sampled at 6 weeks (n = 144) and 6 months (n = 133) using LC-ESI-IM-qTOF-MS. Infections in infants were assessed using physician-reported questionnaires at 1 and 2 years. Modified Poisson regression was used to assess associations, adjusted for relevant covariates and corrected for multiple testing (FDR < 0.010).

Results

Higher levels of fucosyl(1-3)-iso-lacto-N-octaose,

SUBMITTER: Siziba LP 

PROVIDER: S-EPMC12714623 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature