Multiparametric quantitative MRI combining SyMRI and MUSE-DWI for noninvasive stratification of HER2 status in breast cancer.

ABSTRACT:

Background

Accurate stratification of HER2 status is crucial for treatment decision-making and prognostic evaluation in breast cancer. With the recognition of HER2-low as a distinct subtype, which has recently gained clinical relevance as HER2-low patients may benefit from emerging HER2-targeted therapies, conventional pathological methods remain the gold standard; however, they are invasive and prone to sampling bias, and may not fully reflect intratumoral heterogeneity. Imaging provides a noninvasive alternative for evaluating HER2 expression. This study aimed to assess the value of synthetic MRI (SyMRI) combined with multiplexed sensitivity encoding diffusion-weighted imaging (MUSE-DWI) for noninvasive stratification of HER2 status in breast cancer.

Methods

A total of 138

SUBMITTER: Yang K 

PROVIDER: S-EPMC12714661 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature