4-Phenylbutyric acid extends the gold time of uncontrolled hemorrhagic shock at high altitude by alleviating vital organ injury.

ABSTRACT:

Background

Uncontrolled hemorrhagic shock (UHS) is prevalent in military operations, disaster relief, and traffic accidents at high altitudes. Due to reduced tolerance to resuscitation fluids and prolonged evacuation times, its management poses substantial challenges. Whether 4-phenylbutyric acid (PBA) can protect vital organ function and extend the golden period for UHS at high altitudes remains unclear.

Methods

Rats airlifted from Chongqing to Lhasa were used to establish a UHS model. The experiment consisted of three parts: Part 1 investigated PBA's effect on extending the golden period (prehospital treatment window). Specifically, using a high-altitude rat model of UHS, we observe the duration that PBA + LR maintains mean arterial pressure (MAP) at 50-60 mmHg without def

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12714675 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature