An improved porcine model of infrarenal abdominal aortic aneurysm.

ABSTRACT: Abdominal aortic aneurysm (AAA) remains a significant public health challenge, primarily due to its high mortality rate and the lack of effective preventive and causal strategies. This study aims to establish an improved translational triple-hit porcine model of AAA and to compare it with human AAA disease. AAA was induced in four juvenile domestic pigs by balloon catheter-based aortic dilation, enzyme-mediated extracellular matrix (ECM) degradation, and lysyl oxidase inhibition. The porcine AAA model was characterized by proteomics, histological investigation, and cytokine profiling, and compared with natural occurred human AAA disease. Infrarenal AAA was successfully established with sustained aortic dilation (> 150% of baseline diameter) occurring within 7-14 days post induction and mai

SUBMITTER: Stei M 

PROVIDER: S-EPMC12714784 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature