Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques.

ABSTRACT: Broadly neutralizing antibodies (bNAbs) against HIV have demonstrated robust protective efficacy against sensitive viruses in humans and nonhuman primates. However, the potential of rare resistant viral variants to abrogate bNAb-based protection remains to be determined. Here we show that simian-human immunodeficiency virus (SHIV) challenge containing minor resistant variants can compromise protective efficacy of the V2-specific bNAb PGDM1400 in rhesus macaques. Macaques were infused with PGDM1400 and challenged intrarectally with either 500 monkey infectious dose 50 (MID50) of the PGDM1400-sensitive virus SHIV-325C or with 500 MID50 of SHIV-325C mixed with a sub-infectious 0.5 or 0.05 MID50 dose of the PGDM1400-resistant virus SHIV-SF162P3. All PGDM1400-treated animals challenged with SHI

SUBMITTER: Walker-Sperling VEK 

PROVIDER: S-EPMC12714793 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature