Flexible and elastic chitosan-based hydrogel film dressings for second-degree partial-thickness burn wound healing.

ABSTRACT: Chitosan (CS)-based hydrogel films have attracted intense and increasing interest for healing burn wounds owing to their strong biocompatibility and hemostatic potential. However, conventional CS hydrogels suffer from poor mechanical strength and structural instability under exudate exposure, limiting their clinical efficacy. Herein, a floccule self-deposition/redissolution strategy is implemented to develop a flexible and transparent CS-based hydrogel film with enhanced hemostasis and wound healing properties. Acetic acid is used to redissolve CS floccules, expanding intermolecular distances to reduce intramolecular hydrogen bonds and expose more bioactive amino groups. Glycerin is incorporated as a plasticizer to enhance the mechanical properties. The as-prepared CS-based hydrogel film e

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12714855 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature