Risk factors for macrophage activation syndrome in systemic juvenile idiopathic arthritis: a systematic review and meta-analysis.

ABSTRACT:

Background

Macrophage activation syndrome (MAS) is among the most life-threatening complications of systemic juvenile idiopathic arthritis (sJIA). Early identification of risk factors is critical for reducing mortality. However, existing evidence is markedly heterogeneous and lacks quantified, comparable, and clinically translatable conclusions.

Methods

We systematically searched PubMed, Web of Science, EMBASE, and Chinese databases, including China national knowledge infrastructure (CNKI), Wanfang, VIP, and Chinese biomedical literature database (CBM), from inception to 1 July 2025, for case-control studies investigating risk factors for MAS in sJIA. Two investigators independently screened studies, extracted data, and assessed study quality. Meta-analyses were performed us

SUBMITTER: Li S 

PROVIDER: S-EPMC12714893 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature