New serum soluble factors predicting inflammatory and non-inflammatory disability worsening in multiple sclerosis.

ABSTRACT:

Introduction

Serum neurofilament light chains (sNfL) and glial fibrillary acidic protein (sGFAP) associate respectively with acute inflammation and smoldering disease in relapsing-remitting multiple sclerosis (MS) patients. We explored the proteomic profile associated with the different combinations of low or high levels of sNfL and sGFAP to explore immune mechanisms involved in different MS outcomes.

Methods

Multicenter cross-sectional study including 253 treatment-naïve PwMS, and 180 healthy controls (HCs). sNfL and sGFAP levels were measured via SIMOA and patients were classified according to their levels into four groups: NLGL (normal sNfL and sGFAP), NHGL (high sNfL/normal sGFAP), NHGH (high sNfL and sGFAP), and NLGH (normal sNfL/high sGFAP). Serum proteomics were measu

SUBMITTER: Rodero-Romero A 

PROVIDER: S-EPMC12714895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature