The efficacy and safety of endoscopic surgery combined with platelet-rich plasma for lumbar disk herniation: a systematic review and meta-analysis.

ABSTRACT:

Objective

Lumbar disk herniation (LDH) is a common spinal disorder with an increasing annual incidence, significantly impairing patients' quality of life. In recent years, platelet-rich plasma (PRP) has emerged as a viable biologically based treatment alternative in clinical practice. The present study aimed to conduct a thorough review and meta-analysis to systematically assess the safety and effectiveness of endoscopic surgery combined with PRP for the treatment of LDH.

Methods

A comprehensive search was conducted across eight databases from their inception until October 2025 to identify relevant articles assessing the efficacy of PRP therapy for LDH. Two independent reviewers carefully reviewed and selected studies using predefined inclusion and exclusion criteria. Furthe

SUBMITTER: Guo G 

PROVIDER: S-EPMC12714916 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature