Assessing neurobiology of lifelong premature ejaculation through brain MRI structural similarity gradient.

ABSTRACT:

Objective

This study explored the gradient changes in structural similarity based on the cortical structure of patients with lifelong premature ejaculation (LPE) and further analyzed the characteristics of the associations between these changes and clinical phenotypes, gene expression profiles, and neurotransmitter distributions.

Materials and methods

This study employed a novel method, morphological inverse divergence (MIND), to construct structural similarity gradients for 62 LPE patients and 53 healthy controls. Between-group comparisons were performed to examine the abnormalities in gradients among LPE patients. Partial least squares regression analysis explored the relationships between gene expression profiles and gradient changes, as well as neurotransmitter expressio

SUBMITTER: Deng Q 

PROVIDER: S-EPMC12715095 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature