Endocrine complications in patients with β-thalassemia major receiving iron-chelation therapy.

ABSTRACT:

Background

β-Thalassemia major patients are frequently vulnerable to endocrine dysfunction due to iron overload from chronic transfusions. This impairs growth, thyroid function, glucose metabolism, and bone health, ultimately compromising quality of life and long-term outcomes.

Objectives

This study investigates the prevalence and pattern of endocrine dysfunction in β-thalassemia major patients receiving iron-chelation therapy and explores associations with iron overload markers.

Methods

This case-control study involved 60 β-thalassemia major patients and 20 age- and sex-matched controls. Hormonal and biochemical parameters were measured and linked to iron status.

Results

Among β-thalassemia major patients (7-35 years), 73.3% (n = 44/60) were splenectomi

SUBMITTER: Al-Sanabra OM 

PROVIDER: S-EPMC12715153 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature