Identifying global trends from case reports of fibrodysplasia ossificans progressiva: a scoping review.

ABSTRACT:

Background

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, disabling, genetic disorder characterized by progressive heterotopic ossification (HO). FOP care pathways are complex, and there are many underrepresented patients globally.

Objectives

This scoping review aimed to identify global FOP case reports and investigate real-world management practices.

Evidence sources eligibility criteria and charting methods

International/local databases and congress proceedings were searched. Publications reporting patient-level data for ⩾1 patient with an FOP primary diagnosis, published January 2000-January 2024, were eligible. Publication details, patient demographics, disease presentation, and care pathway were extracted. Data were charted through categorization o

SUBMITTER: Scott C 

PROVIDER: S-EPMC12715164 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature