Emergence of amoxicillin resistance in refractory <i>Helicobacter pylori</i> infection.

ABSTRACT:

Objectives

This study investigated temporal changes in resistance patterns among treatment-refractory Helicobacter pylori infections in Taiwan.

Background

Antibiotic resistance in H. pylori is a growing global concern.

Design

We retrospectively analyzed adult patients at Linkou Chang Gung Memorial Hospital (2018-2024) with ⩾2 prior eradication failures and confirmed active infection via [13C]-urea breath test.

Methods

Gastric biopsy specimens were cultured, and antimicrobial susceptibility testing was performed using the Epsilometer test for amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifabutin, ciprofloxacin, and moxifloxacin. Breakpoints were defined according to the European Committee on Antimicrobial Susceptibility

SUBMITTER: Lin CY 

PROVIDER: S-EPMC12715165 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature