Effect of microbubble-assisted gemcitabine delivery with repeated ultrasound exposure in a pancreatic cancer organ-on-a-chip model.

ABSTRACT: The fibrotic stroma of solid tumours poses a physical barrier to drug delivery and effective treatment. Interaction between cancerous epithelial cells and their surrounding stromal partners results in the development of a rigid, collagenous matrix environment with reduced interstitial flow, crucial for drug delivery to cancer cells, particularly in pancreatic ductal adenocarcinoma (PDAC), an aggressive pancreatic cancer with poor prognosis. Therefore, evaluating novel drug delivery mechanisms using appropriate stroma-mimicking 3D culture models is essential. We previously demonstrated, using a 21-day cultured microfluidic PDAC model that mimics the rigid, collagenous stroma, reduced interstitial flow through the tumour model. In this study, we evaluated the use of microbubbles and ultrasou

SUBMITTER: Kpeglo D 

PROVIDER: S-EPMC12715219 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature