Mediators of the association between psychological distress and mortality in people diagnosed with cancer.

ABSTRACT: The biological and behavioural mechanisms linking psychological distress to excess mortality in people living with and beyond cancer (LWBC) remain poorly understood. In this multi-cohort study, we examine the associations between psychological distress and both cancer-specific and all-cause mortality in individuals living with and beyond cancer (LWBC), and assess the potential mediating roles of inflammation and health behaviours. The primary analysis includes 13,349 adults from the UK Biobank (2006-2021), with replication in 5739 participants from the Finnish Public Sector study (2000-2018). Psychological distress is associated with an increased risk of all-cause mortality (pooled adjusted risk ratio (RR), 1.54; 95% confidence interval (CI), 1.37-1.74) and cancer mortality (pooled RR, 1.5

SUBMITTER: Miller NE 

PROVIDER: S-EPMC12715235 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature