Multi-Site Theta-tACS Improves Memory and Language Performance and Associated Local and Remote Functional Connectivity in Mild Cognitive Impairment.

ABSTRACT:

Background

While multi-site noninvasive brain stimulation demonstrates enhanced cognitive benefits in mild cognitive impairment (MCI), the efficacy of transcranial alternating current stimulation (tACS) in this paradigm remains unestablished. The study aims were to investigate the therapeutic effects of multi-site tACS on MCI patients and its underlying neural mechanism.

Methods

A parallel, sham-controlled trial was conducted with 60 MCI participants assigned to multi-site tACS (prefrontal gyrus and precuneus), single-site tACS (precuneus), or sham groups. All participants underwent 20 days of 7 Hz tACS concurrent with working memory training. Cognitive assessments and fMRI examinations were performed pre- and post- intervention. Local and remote functional connectivity chan

SUBMITTER: Guo Z 

PROVIDER: S-EPMC12715273 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature