Unusual Oral Presentations of Herpes Simplex Virus-1: A Series of Eight Cases and Literature Review.

ABSTRACT:

Aims

The aim of this study is to characterize the clinical and microscopic features of recurrent oral/labial HSV-1 infection with unusual clinical presentations.

Methods

A literature review and retrospective case series of patients with recurrent oral/labial HSV-1 with unusual presentations were conducted. Data were collected from medical records, and all cases were confirmed by histopathology and immunohistochemistry.

Results

Eight patients (five males, 62.5%; three females, 37.5%) with a mean age of 61.8 years presented with unusual HSV-1 manifestations, including solitary lesions, white plaque-like appearance, non-keratinized site involvement, or prolonged duration. Lesions involved the tongue border (n = 4, 50%), anterior ventral tongue, hard palate, posterior rid

SUBMITTER: de Paiva JPG 

PROVIDER: S-EPMC12715298 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature