A Real-World Study on Unstable Parkinson's Disease: Levodopa Dosage Management and the Role of Nonmotor Symptoms.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative disorder associated with motor and nonmotor symptoms.

Objectives

This study assesses levodopa dose management, the therapeutic goals of clinicians, the factors that influence clinicians' choice of therapy, and the role of nonmotor symptoms using real-world evidence from Germany, Italy, and Spain.

Methods

To assess the management of unstable PD patients on levodopa-containing regimens, neurologists were asked to complete questionnaires (n = 181) and prospective electronic patient records (EPR) were collected (n = 2687). Neurologists were asked questions about their practice and approach to unstable PD patients. EPRs were completed by neurologists after each visit with patients, and the objectives of any changes

SUBMITTER: Stocchi F 

PROVIDER: S-EPMC12715329 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature