Urinary biomarkers in multicentric studies: Shaping the future of bladder cancer diagnosis and follow-up.

ABSTRACT:

Background and objective

Bladder cancer (BC), a prevalent malignancy, poses significant diagnostic and surveillance challenges due to its high recurrence rates and reliance on cystoscopy, an invasive procedure for diagnosis and monitoring. While urine-based genomic and proteomic biomarkers offer promising non-invasive alternatives, their clinical implementation remains limited. This review synthesizes evidence from multicentric studies on urinary biomarkers for BC and evaluates their potential in reducing unnecessary invasive cystoscopies.

Methods

A comprehensive review of literature was conducted searching for multicentric studies on urine-based genomic and proteomic biomarkers for BC detection and/or surveillance. MEDLINE/Pubmed, Embase and Scopus databases and BJUI, UroTo

SUBMITTER: Martel A 

PROVIDER: S-EPMC12715348 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature