One Side or Two? A Systematic Review of Deep Brain Stimulation Approaches in Movement Disorders.

ABSTRACT:

Background

Deep brain stimulation (DBS) is an established treatment for movement disorders such as Parkinson's disease (PD) and essential tremor (ET). However, the decision between unilateral, staged bilateral, or simultaneous bilateral DBS remains controversial, influenced by clinical presentation, patient preferences, and economic factors.

Objective

The aim was to compare motor score improvements, adverse events (AE), incremental benefits, and progression with unilateral to bilateral procedures and the rationale for second-side surgery.

Methods

This systematic review examined studies on patients treated with unilateral or bilateral (simultaneous or staged) DBS from 1999 to 2025, focusing on outcomes, safety, and efficacy.

Results

In PD, unilateral DBS targeti

SUBMITTER: Vetkas A 

PROVIDER: S-EPMC12715356 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature