Comprehensive Transcriptomic and Bioinformatic Analysis of the Mechanism of Buzhong Yiqi Decoction in the Improvement of Diabetic Nephropathy.

ABSTRACT:

Background

Buzhong Yiqi decoction (BZYQ) is a classical traditional Chinese formula that has shown potential in alleviating diabetic nephropathy (DN). However, its underlying mechanisms remain unclear.

Objective

We aimed to explore the potential targets and mechanisms of action of BZYQ in DN.

Materials and methods

A DN rat model was induced using a high-fat and high-sugar diet combined with intraperitoneal injection of streptozotocin (STZ), followed by treatment with different doses of BZYQ. Initially, the protective effects of BZYQ on renal tissue were assessed by measuring fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), 24-hour urinary total protein (24h-UTP), urinary albumin (ALB), and serum creatinine (SCr) after administration, along with

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12715389 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature