Abstinence Alters Triple Network Dynamics in Moderate-to-Heavy Drinkers.

ABSTRACT: Alcohol misuse is a significant public health concern, yet little is known about the neural dynamics associated with habitual heavy drinking, particularly during abstinence. The Triple Network Model, comprising the salience network (SN), default mode network (DMN), and central executive network (CEN), provides a framework for understanding large-scale brain network dysfunction associated with heavy alcohol use. Using resting-state fMRI and a Hidden Semi-Markov Model (HSMM), we examined dynamic brain state changes in moderate-to-heavy drinkers (n = 38) across two conditions: typical drinking and alcohol abstinence. Our findings revealed six distinct brain states, with significant differences in state occupancy, transitions, and duration between drinking conditions. Abstinence was associated

SUBMITTER: Khodaei M 

PROVIDER: S-EPMC12715413 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature