Development and internal validation of an age less-dependent frailty score in the cardiovascular health study.

ABSTRACT:

Background

Frailty is a proxy for biologic aging that confers risk independently of chronologic age. Most frailty indices correlate strongly with chronologic age, making independent features of biologic aging challenging to identify.

Methods

We aimed to create a novel Age Less-Dependent Frailty (AGELESS) Score less-associated with chronologic age than the Fried frailty phenotype. Among Cardiovascular Health Study participants with available echocardiographic data, we identified demographic, clinical, serologic, and echocardiographic variables more correlated with a continuous version of the Fried frailty phenotype than age, then used LASSO regression for variable selection. In a 25% leave-out sample, we internally validated the score's association with age-adjusted all-cause

SUBMITTER: Troy AL 

PROVIDER: S-EPMC12715521 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature