In Situ Photoactivated Hydrogel Adhesive Dressings for Post Colon Polypectomies (PolypCures).

ABSTRACT: Colon polypectomy is a widely performed endoscopic procedure that reduces the incidence of colorectal cancer but leaves exposed colonic wounds susceptible to bleeding, perforation, and infection. The current standard of wound care, mechanical clips, is limited by technical complexity, high cost, and poor efficacy for large (> 2 cm in diameter) or difficult-to-access lesions. Here, we present PolypCure, an in situ photoactivated hydrogel adhesive dressing delivered via a single catheter, through either oozing or spraying methods, to achieve rapid, spatiotemporally controlled sealing and hemostasis (within 2 min) of colon lesions using the white light source integrated into standard endoscopic instruments. The hydrogel, composed of norbornene- and thiol-functionalized polyethylene gly

SUBMITTER: Hu X 

PROVIDER: S-EPMC12715553 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature