The metabolite ILA of <i>Akkermansia muciniphila</i> improves AP-related intestinal injury by targeting and inhibiting CASP3 activity.

ABSTRACT:

Objective

Acute Pancreatitis (AP) is a common acute abdominal disease in clinical practice. The gut microbiome is recognized as a key regulator in the development of acute pancreatitis. Akkermansia muciniphila (AKK) is recognized as a functional probiotic strain and has a beneficial effect on the progression of many diseases. However, the role of the AKK in the development of AP remains unclear. Here, we evaluated the potential contribution of AKK to AP.

Design

Relative abundance of gut microbial AKK in AP was evaluated. A rat model of acute pancreatitis was established by retrograde pancreatic duct infusion of sodium taurocholate. Non-targeted and targeted metabolomics analysis were used for metabolites analysis.

Results

We first found that the relative abunda

SUBMITTER: Li P 

PROVIDER: S-EPMC12715610 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature