Incorporation of a Natural Deep Eutectic Solvent-Based System as a Cryoprotectant in Solid Lipid Nanoparticles: Advancing toward Industrial Scalability.

ABSTRACT: The industrial-scale production of solid lipid nanoparticles (SLNs) faces significant challenges, such as degradation during freezing and the reliance on toxic solvents for cryoprotection and active ingredient solubility, hindering their effective storage and commercialization. This study presents an innovative and sustainable approach to SLNs formulation by incorporating a natural deep eutectic solvent-based system (NaDES) as an integral part of the system. The research evaluated the cryoprotective potential of NaDES at different concentrations and freezing methods, demonstrating their ability to stabilize aluminum chloride phthalocyanine (AlClPc)-loaded SLNs during freezing and enable drying protocols to enhance particle concentration. SLNs formulations with high colloidal stability were

SUBMITTER: Florencio I 

PROVIDER: S-EPMC12715630 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature