Epstein-Barr virus⁺ inflammatory follicular dendritic cell sarcoma with clonal immunoglobulin heavy chain gene rearrangement: A case report and literature review.

ABSTRACT: Epstein-Barr virus⁺ inflammatory follicular dendritic cell sarcoma (EBV⁺ IFDCS) is a tumor with relatively inert biological behavior and low malignancy. Due to the lack of clinical features and non-specific imaging examinations, EBV⁺ IFDCS is difficult to diagnose preoperatively. The histological morphology and immunophenotype of EBV⁺ IFDCS are very broad, in which the presentation of EBV⁺ IFDCS with marked granulomatous changes is rare and can be confused with other granulomatous diseases. The present study reported a case of EBV⁺ IFDCS with marked granuloma formation. Notably, the present case report detected gene rearrangements using PCR-capillary electrophoresis and identified an amplification peak in the DH7-JH region o

SUBMITTER: Ye Q 

PROVIDER: S-EPMC12715663 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature