Electroencephalography-based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high-risk for progression to dementia.

ABSTRACT:

Introduction

Mild cognitive impairment (MCI) represents a transitional state between normal aging and dementia, with 30%-50% of cases progressing to dementia. However, some individuals remain stable over time, even when presenting biomarker profiles that indicate high risk. Understanding the neural mechanisms underlying this resilience is essential for developing targeted preventive strategies.

Methods

Within the Italian INTERCEPTOR project, we investigated electroencephalography (EEG) markers of resilience in MCI individuals who exhibited reduced hippocampal volume and abnormal fluorodeoxyglucose-positron emission tomography (FDG-PET) at baseline but remained stable and did not progress to dementia after 36 months. Two MCI subgroups were compared: those who do not convert (

SUBMITTER: Pappalettera C 

PROVIDER: S-EPMC12715696 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature