Immediate reactions to amyloid PET disclosure in Japanese older adults without dementia.

ABSTRACT:

Introduction

Amyloid positron emission tomography (PET) has become increasingly important for detection of early Alzheimer's disease (AD) and eligibility for emerging disease-modifying therapies. While North American and European studies report limited short-term psychological harm following disclosure of amyloid status in asymptomatic individuals, evidence in non-North American and European contexts is scarce. We evaluated the immediate psychological impact of amyloid PET disclosure in a large Japanese cohort without dementia.

Methods

We analyzed data from 630 cognitively unimpaired Clinical Dementia Rating global score (CDR-GS of 0, 70%) or mild cognitive impairment (CDR-GS of 0.5, 30%) participants 50-85 years of age enrolled in the Japanese Trial-Ready Cohort onsite stud

SUBMITTER: Sato K 

PROVIDER: S-EPMC12715704 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature