AD-related plasma biomarkers in centenarians: links to cognition and neuropathology.

ABSTRACT:

Introduction

Whether Alzheimer's disease (AD)-associated plasma biomarkers reflect cognitive performance and neuropathology in the oldest old remains unclear.

Methods

In plasma samples from 255 centenarians from the longitudinal 100-plus Study (median age 101.2 years), we quantified biomarkers amyloid beta (Aβ)42/40 ratio, Aβ40, Aβ42, phosphorylated tau 181 (pTau-181)/Aβ42 ratio, pTau-181, neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) concentrations. These were associated with same-day measures of cognitive performance and, for centenarians who donated their brain (n = 60), with post mortem Aβ and tau neuropathology.

Results

Cognition ranged from high to early cognitive decline (median Mini-Mental State Examination [MMSE] score = 26). Lower pla

SUBMITTER: Lorenz LMC 

PROVIDER: S-EPMC12715708 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature