Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging.

ABSTRACT:

Introduction

Disruption of the autophagy-lysosomal pathway (ALP) compromises proteostasis and contributes to aging-related proteinopathy. Many studies indicate that a healthy diet can improve cognitive health and reduce the risk of Alzheimer-type pathogenesis.

Methods

Plant-based products were tested in hippocampal explants for amplifying the ALP component cathepsin B (CatB), a protease reported to reduce proteinopathy and synaptopathy. Proof-of-concept experiments also tested Panax quinquefolius extract (PanQ) for improving cognitive function in aging rats.

Results

Among the natural extracts tested, PanQ emerged as the most effective for increasing the active CatB isoform in correspondence with enhanced levels of synaptic proteins and the autophagy marker LC3-II. Pan

SUBMITTER: Almeida MF 

PROVIDER: S-EPMC12715780 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature