π-Extended Ru-COUBPY Photosensitizers for <i>In Vivo</i> Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light.

ABSTRACT: Photodynamic therapy (PDT) is a promising cancer treatment modality, offering precise spatial and temporal control of drug activation using light. However, clinical translation of current photosensitizers (PSs) is limited by inefficient activation at wavelengths within the phototherapeutic window, especially in the deep-red and near-infrared (NIR) region. NIR light provides advantages such as reduced absorption by endogenous chromophores, minimized tissue photodamage, and improved tissue penetration, highlighting the need for PSs to be activatable in this range. Herein, we report a novel series of ruthenium(II) polypyridyl complexes (Ru4-7) featuring π-extended COUBPY ligands, designed via a vinylogation strategy and synthesized through an innovative postcoordination ligand a

SUBMITTER: Abad-Montero D 

PROVIDER: S-EPMC12715793 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature