Uncovering human kinase substrates in nipah proteome.

ABSTRACT: Nipah virus (NiV) is a zoonotic pathogen that causes recurrent outbreaks with considerable implications for public health. Viruses engage host kinases to phosphorylate viral proteins, aiding replication and host disruption. Identifying NiV phosphoproteins and their host kinases is therefore critical for understanding the mechanism of infection and developing therapeutics. We performed kinase-substrate phosphomotif analysis based on prior studies and employed computational tools to identify putative phosphosites in NiV proteins and corresponding host kinases. Redundancy analysis highlighted key kinases capable of phosphorylating multiple NiV proteins and high-potential viral substrates. Integration with human-viral protein-protein interaction data revealed human kinase substrate proteins in

SUBMITTER: Shaji V 

PROVIDER: S-EPMC12715814 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature