DRESS Syndrome in Patients With Drug-Induced Liver Injury: Characteristics and HLA Risk Factors.

ABSTRACT:

Introduction

Drug reaction with eosinophilia and systemic symptoms (DRESS) can sometimes occur in patients with drug-induced liver injury (DILI). However, detailed studies of DRESS in patients with DILI from the United States are lacking. We investigated the characteristics and human leukocyte antigen (HLA) risks for DILI who also developed DRESS.

Methods

Patients with definite, highly likely, or probable DILI enrolled into US DILI Network studies between September 2004 and August 2023 were included. DRESS was defined based on modified RegiSCAR criteria. HLA alleles were compared between DILI-DRESS cases and 2 control groups (DILI with non-DRESS rash [n = 244] and DILI without rash [n = 1,637]).

Results

Of 2,121 participants with DILI during the study period, 128 part

SUBMITTER: Rahnama-Moghadam S 

PROVIDER: S-EPMC12715855 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature