Comparative Analysis on the Efficacy of Monopolar Radiofrequency With Continuous Water Cooling and Conventional Cryogen Spray Cooling in Facial Rejuvenation.

ABSTRACT:

Background

Monopolar radiofrequency (MRF) is widely used for non-invasive facial rejuvenation.

Objective

In this study, we compared the clinical efficacy and patient-reported procedural pain of a novel MRF system with continuous water cooling (RF-CWC) versus conventional MRF with cryogen spray cooling (RF-CSC) in 22 Asian women.

Methods

In this prospective, randomized, split-face, single-blind trial, 22 participants received a single session of both RF-CWC and RF-CSC. Clinical outcomes-including changes in pore size, elasticity, skin density, fine lines, and lifting-were assessed over 8 weeks using quantitative measurements and investigator-assessed global improvement scores. Procedural pain was also recorded. To support the clinical findings, an ex vivo model

SUBMITTER: Roh H 

PROVIDER: S-EPMC12715870 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature