Polyunsaturated Fatty Acids and Skin Cancer: Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have suggested associations between dietary polyunsaturated fatty acids (PUFAs) and cancer risk; however, causal inference regarding skin cancer remains limited due to potential recall bias, confounding, and reverse causation.

Objective

This study aimed to evaluate the causal association between genetically predicted circulating PUFA levels and the risk of skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.

Methods

We conducted a 2-sample Mendelian randomization (MR) study using genome-wide association study summary statistics from the UK Biobank (PUFAs, n=115,006) and the FinnGen consortium (BCC, n=26,272; SCC, n=4,663; melanoma, n=5,753). Genetic instruments were derived for omega-3, docos

SUBMITTER: Kim G 

PROVIDER: S-EPMC12715871 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature