Sex-specific associations between hypertensive disorders in pregnancy and fetal and placental weight.

ABSTRACT:

Importance

Hypertensive disorders in pregnancy (HDPs) are common and increase the risk of maternal and fetal morbidity and mortality. HDPs may impact fetal growth; however, sex-specific effects have been understudied.

Objective

To examine whether sex-specific differences exist in the association between HDPs and birthweight and placental weight.

Methods

A birth cohort based in Detroit, Michigan, was utilized (n = 1258). HDPs and birthweight were abstracted from medical records; placental weight was obtained from placental pathology reports. Linear regression was used to model sex-specific associations, after multiple imputation, confounder adjustment, and inverse probability weighting to account for selection bias.

Results

The primary analysis included a

SUBMITTER: Sitarik AR 

PROVIDER: S-EPMC12715893 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature