Enhanced risk of thrombosis in aged insulin-treated diabetic rats exposed to non-severe recurrent hypoglycemia.

ABSTRACT:

Background

Antidiabetic treatment is linked with an increased risk of hypoglycemia. Several clinical studies have demonstrated that hypoglycemia exposure elevates the risk of cardiovascular diseases in diabetic patients. Our previous research has shown that non-severe recurrent hypoglycemia (RH) exposure increases the risk of thrombosis in young insulin-treated diabetic (ITD) rats. Given that a substantial subset of diabetes patients who experience cardiovascular complications are elderly and the effect of non-severe RH on thrombosis risk in aged subjects remains unknown, we tested the hypothesis that prior RH exposure enhances thrombosis in aged ITD rats.

Methods

Aged, insulin-treated streptozotocin-diabetic Wistar rats of both sexes were randomly assigned to either the rec

SUBMITTER: Rehni AK 

PROVIDER: S-EPMC12715970 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature