Strain-dependent contribution of the AcrAB-TolC efflux pump to <i>Klebsiella pneumoniae</i> physiology.

ABSTRACT: Klebsiella pneumoniae is a prominent opportunistic pathogen increasingly associated with multidrug resistance and virulence. One of the main mechanisms of antimicrobial resistance in K. pneumoniae is active efflux, primarily mediated by the resistance-nodulation-division (RND) family of pumps. AcrAB-TolC is the key RND efflux pump in K. pneumoniae, regulated by the transcriptional activator RamA and its repressor RamR. Although overexpression of AcrAB-TolC has been linked to drug resistance in various clinical strains, its physiological roles in K. pneumoniae remain insufficiently studied. In this study, we generated isogenic deletions of acrB and ramR in both the genetically tractable K. pneumoniae Ecl8 and the virulent ATCC 43816 strains.

SUBMITTER: Bhogal K 

PROVIDER: S-EPMC12715972 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature