Amazonian Cyanobacteria as a Source of Bioactive Compounds With Antimicrobial and Cytotoxic Properties.

ABSTRACT: Cyanobacteria are photosynthetic microorganisms known for producing diverse bioactive compounds. This study explores the bioactivity of extracts and fractions from Amazonian cyanobacteria and their pigment and phenolic compound production. A fraction from Synechococcus sp. CACIAM 05 showed cytotoxicity against hCMEC/D3 and MG-63 cells. UPLC-HRMS/MS analysis of this fraction (C5FD) identified pheophytin and phorbide derivatives as key bioactive molecules. In antimicrobial assays, another fraction from the same strain exhibited bactericidal activity against Bacillus subtilis ATCC 6633, with a MIC of 40 µg mL^-1. Additional strains also showed antibacterial effects, though with higher MICs. Allelopathic activity identified eleven bioactive strains, including a synergistic effect bet

SUBMITTER: Cavalcante do Amaral S 

PROVIDER: S-EPMC12715989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature