Rosemary Essential Oil Microemulsion for Fungal Keratitis Treatment.

ABSTRACT: This study investigated the use of Rosmarinus officinalis (rosemary) essential oil in a microemulsion (ME) formulation for the treatment of ocular fungal keratitis, a serious infection that can lead to blindness. The ME was characterized in terms of pH, stability, homogeneity, osmolarity, and other physicochemical properties. The Hen's Egg Test-Chorioallantoic Membrane assay was used to assess ocular irritancy, and antifungal efficacy was evaluated using the minimum inhibitory concentration method. The oil extraction yielded 1.2%, with eucalyptol (37.89%) as the major compound. The formulation showed a suitable pH (6.96), particle size of 11.35 nm, good stability, and was classified as non-irritant with an irritation score = 1.5. It exhibited strong antifungal activity against Candida para

SUBMITTER: Ribeiro S 

PROVIDER: S-EPMC12715995 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature